Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
5.8
USERS' SCORE
Good
Based on 76 Reviews
8.5
Supplement Facts
Serving Size: 3 Veg Capsules
Amount Per Serving
%DV
Calories
10
Total Carbohydrate
2 g
<1%**
Sodium
150 mg
7%
Glucosamine Sulfate(from 1,500 mg Glucosamine PotassiumSulfate Complex)
1.1 g (1,100 mg)
†
Chondroitin Sodium Sulfate(from Bovine Cartilage)
1.2 g (1,200 mg)
†
MSM (Methylsulfonylmethane)
300 mg
†
Top Medical Research Studies
8
We explored the effects of methylsulfonylmethane (MSM) on knee pain through a well-structured randomized, double-blind, placebo-controlled trial.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
Read More
4
We conducted a double-blind, randomized controlled trial to assess the effectiveness of methylsulfonylmethane (MSM) for knee osteoarthritis (OA). Fifty participants aged 45 to 90 received either MSM or a placebo over 12 weeks.
Although we observed some improvement in pain and physical function for those taking MSM, these changes were minimal and may not hold clinical significance. Hence, while there are some positive effects, the overall benefits of MSM for treating knee OA remain uncertain.
Although we observed some improvement in pain and physical function for those taking MSM, these changes were minimal and may not hold clinical significance. Hence, while there are some positive effects, the overall benefits of MSM for treating knee OA remain uncertain.
Read More
2
We examined the impact of methylsulfonylmethane (MSM) on knee pain in military trainees. In a randomized controlled trial, 180 participants, aged 18 to 40, either received 3 grams of MSM or a placebo for 8 weeks.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
Read More
Most Useful Reviews
9
Reduced knee pain
202 people found this helpful
Glucosamine, a major component of cartilage tissue, protects joints from damage and has a shock-absorbing effect. It also contributes to the synovial fluid, which lubricates and nourishes the joints. Chondroitin aids in producing joint fluid and restoring cartilage, possessing anti-inflammatory and analgesic properties. Together, glucosamine and chondroitin effectively protect and restore cartilage. Since I began taking them, I’ve noticed my knee almost never hurts, and I’ve even observed improvements in my hair and nails.
Read More
9
Weak joints helped
105 people found this helpful
It helps with weak knee joints; I recommend it!
Read More
9
Knee pain relief
87 people found this helpful
I bought this a year ago based on my trainer's recommendation for physical exercise. Initially, I didn't notice much and didn't repurchase it. Then, after a period of running and cycling, one knee was in agony for a month. I ordered it again and, after a month of consistent use, my knee no longer bothered me. Now, I take this supplement periodically, as it helps replenish joint functions. I wasn't sure about these supplements initially, but I’ve grown to trust them.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
5.8
- All Researches
8
We explored the effects of methylsulfonylmethane (MSM) on knee pain through a well-structured randomized, double-blind, placebo-controlled trial.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
Read More
8
We assessed the impact of an 8-week joint pain supplement, Instaflex™, on adults aged 50-75 experiencing knee pain. In a randomized, double-blind, placebo-controlled trial with 100 participants, we measured changes in pain, stiffness, and daily function.
Our findings revealed that Instaflex™ significantly reduced knee pain severity and improved the ability to perform daily activities, particularly beneficial for those suffering from chronic knee discomfort. This suggests that the supplement could be a helpful option for managing knee pain in older adults.
Our findings revealed that Instaflex™ significantly reduced knee pain severity and improved the ability to perform daily activities, particularly beneficial for those suffering from chronic knee discomfort. This suggests that the supplement could be a helpful option for managing knee pain in older adults.
Read More
7
We conducted a randomized, double-blind, placebo-controlled trial to see if methylsulfonylmethane (MSM) helps alleviate knee pain in people with osteoarthritis. Over 12 weeks, participants took either 3g of MSM or a placebo, twice daily.
We observed significant improvements in pain and physical function for those taking MSM compared to the placebo group. However, no major side effects were reported, and some assessments did not show clear benefits. While MSM showed promise, more research is needed to confirm its long-term effectiveness and safety.
We observed significant improvements in pain and physical function for those taking MSM compared to the placebo group. However, no major side effects were reported, and some assessments did not show clear benefits. While MSM showed promise, more research is needed to confirm its long-term effectiveness and safety.
Read More
4
We conducted a double-blind, randomized controlled trial to assess the effectiveness of methylsulfonylmethane (MSM) for knee osteoarthritis (OA). Fifty participants aged 45 to 90 received either MSM or a placebo over 12 weeks.
Although we observed some improvement in pain and physical function for those taking MSM, these changes were minimal and may not hold clinical significance. Hence, while there are some positive effects, the overall benefits of MSM for treating knee OA remain uncertain.
Although we observed some improvement in pain and physical function for those taking MSM, these changes were minimal and may not hold clinical significance. Hence, while there are some positive effects, the overall benefits of MSM for treating knee OA remain uncertain.
Read More
2
We examined the impact of methylsulfonylmethane (MSM) on knee pain in military trainees. In a randomized controlled trial, 180 participants, aged 18 to 40, either received 3 grams of MSM or a placebo for 8 weeks.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
Read More
User Reviews
USERS' SCORE
Good
Based on 76 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced knee pain
202 people found this helpful
Glucosamine, a major component of cartilage tissue, protects joints from damage and has a shock-absorbing effect. It also contributes to the synovial fluid, which lubricates and nourishes the joints. Chondroitin aids in producing joint fluid and restoring cartilage, possessing anti-inflammatory and analgesic properties. Together, glucosamine and chondroitin effectively protect and restore cartilage. Since I began taking them, I’ve noticed my knee almost never hurts, and I’ve even observed improvements in my hair and nails.
Read More
9
Weak joints helped
105 people found this helpful
It helps with weak knee joints; I recommend it!
Read More
9
Knee pain relief
87 people found this helpful
I bought this a year ago based on my trainer's recommendation for physical exercise. Initially, I didn't notice much and didn't repurchase it. Then, after a period of running and cycling, one knee was in agony for a month. I ordered it again and, after a month of consistent use, my knee no longer bothered me. Now, I take this supplement periodically, as it helps replenish joint functions. I wasn't sure about these supplements initially, but I’ve grown to trust them.
Read More
9
Reduced knee pain
53 people found this helpful
Working! After heavy squats and improper running on asphalt destroyed my knees two years ago, this product has truly helped alleviate the morning stiffness and crunching in my knees. I also no longer experience sore feet. I continue taking it as a preventive measure, although there's not much to worry about!
Read More
10
No knee issues
17 people found this helpful
This stuff works! Upon my vet's recommendation, I use one capsule daily for my Bichon. He had leg and knee problems, and since adding this powder, he's experienced no difficulties whatsoever.
Read More
Frequently Asked Questions
9
Significant pain reduction
2 people found this helpful
I began taking Now foods’ glucosamine and MSM on my doctor’s advice for my nagging knee pain. After just six weeks, the pain diminished significantly, and after two months, it completely vanished. I will definitely repurchase it for continued treatment as the composition is excellent.
9
Knee pain relief
87 people found this helpful
I bought this a year ago based on my trainer's recommendation for physical exercise. Initially, I didn't notice much and didn't repurchase it. Then, after a period of running and cycling, one knee was in agony for a month. I ordered it again and, after a month of consistent use, my knee no longer bothered me. Now, I take this supplement periodically, as it helps replenish joint functions. I wasn't sure about these supplements initially, but I’ve grown to trust them.
10
Pain relief achieved
9 people found this helpful
Good stuff! I noticed a difference within days of starting these. I take two every morning and have been using them for three years. My knees no longer hurt, and my finger joint pain is gone. I continue with my weight training without joint discomfort.
10
Knees no longer hurt
7 people found this helpful
About six months ago, I began experiencing knee pain and tried multiple treatments with no success. I hesitantly tried a product from a famous Japanese sesame company, but I doubted it would be effective due to the high cost. After drinking it for five months with a bit of scepticism, I suddenly realised my knees no longer hurt! I can sit upright without discomfort, and even cycling is pain-free now! This is remarkably affordable compared to the sesame company's product. I’m very grateful!
10
Effective arthritis treatment
9 people found this helpful
Super!!! My knees suffer from arthritis. I hesitated to order these tablets, but now I can confidently say that they work wonderfully! I can walk up the stairs, something I couldn’t manage before. I will certainly order more and recommend them to my friends!
9
Helpful for joints
2 people found this helpful
This is a fantastic aid for my 78-year-old mum. She had severe knee and joint aches and needed a cane to walk. After consistently taking this supplement for over a year, her complaints of pain have ceased. It works alongside proper nutrition and gentle exercises.
9
Knee crunch resolved
2 people found this helpful
Joint Support This is not the first time I have purchased this product. I have been taking it for four months; the creaking in my knees and crunching in my hip joints have vanished, and my back feels much better. I take three capsules daily, regardless of meal times. The capsules are not large and are easy to swallow.
9
Highly effective treatment
2 people found this helpful
Very effective! If your back or legs hurt and your knees crunch, glucosamine with chondroitin is truly essential! Combined with digestive enzymes, it quickly targets the pain.
9
Highly recommended support
2 people found this helpful
Regular purchase! I use Glucosamine, chondroitin and MSM as a course because I have arthrosis of my left knee. The combination promotes cartilage tissue regeneration and reduces inflammation. I highly recommend it!
9
Quicker recovery
4 people found this helpful
This is my second order of the product. I first bought it after my knee surgery, and I've noticed a faster recovery process. I can see it in photos and feel the difference, especially after my second knee operation due to sports injuries. I pair it with other supplements to achieve remarkable results. I highly recommend this!
9
Quick positive effect
8 people found this helpful
On the advice of friends, I discovered wonderful supplements on this site! Having had two knee joint replacement surgeries, my mobility is limited. Since I began taking iHerb glucosamine and chondroitin, I noticed a quick positive effect. The capsules are easy to swallow; I take 2 in the morning and one in the evening, and I have not experienced any side effects. I recommend this high-quality product!
10
Eliminates clicking
2 people found this helpful
This really helps! I decided to try it because my knee constantly clicked in all situations. It was concerning to train under heavy weights with this click. I also bought knee pads, but this addition turned out to be more cost-effective. I took 2 capsules daily, while my husband took 3, depending on his weight. Now, my knee doesn’t click, so the product works! I recommend it!
8
We explored the effects of methylsulfonylmethane (MSM) on knee pain through a well-structured randomized, double-blind, placebo-controlled trial.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.
Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.
This suggests that MSM could be a helpful option for those dealing with mild knee pain.
2
We examined the impact of methylsulfonylmethane (MSM) on knee pain in military trainees. In a randomized controlled trial, 180 participants, aged 18 to 40, either received 3 grams of MSM or a placebo for 8 weeks.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
Unfortunately, our findings showed no significant improvements in knee pain levels or mood scores among those taking MSM compared to the placebo group. Although MSM can be safely consumed, it seems it may not effectively prevent knee pain in active individuals.
7
We conducted a randomized, double-blind, placebo-controlled trial to see if methylsulfonylmethane (MSM) helps alleviate knee pain in people with osteoarthritis. Over 12 weeks, participants took either 3g of MSM or a placebo, twice daily.
We observed significant improvements in pain and physical function for those taking MSM compared to the placebo group. However, no major side effects were reported, and some assessments did not show clear benefits. While MSM showed promise, more research is needed to confirm its long-term effectiveness and safety.
We observed significant improvements in pain and physical function for those taking MSM compared to the placebo group. However, no major side effects were reported, and some assessments did not show clear benefits. While MSM showed promise, more research is needed to confirm its long-term effectiveness and safety.
4
We conducted a double-blind, randomized controlled trial to assess the effectiveness of methylsulfonylmethane (MSM) for knee osteoarthritis (OA). Fifty participants aged 45 to 90 received either MSM or a placebo over 12 weeks.
Although we observed some improvement in pain and physical function for those taking MSM, these changes were minimal and may not hold clinical significance. Hence, while there are some positive effects, the overall benefits of MSM for treating knee OA remain uncertain.
Although we observed some improvement in pain and physical function for those taking MSM, these changes were minimal and may not hold clinical significance. Hence, while there are some positive effects, the overall benefits of MSM for treating knee OA remain uncertain.
8
We assessed the impact of an 8-week joint pain supplement, Instaflex™, on adults aged 50-75 experiencing knee pain. In a randomized, double-blind, placebo-controlled trial with 100 participants, we measured changes in pain, stiffness, and daily function.
Our findings revealed that Instaflex™ significantly reduced knee pain severity and improved the ability to perform daily activities, particularly beneficial for those suffering from chronic knee discomfort. This suggests that the supplement could be a helpful option for managing knee pain in older adults.
Our findings revealed that Instaflex™ significantly reduced knee pain severity and improved the ability to perform daily activities, particularly beneficial for those suffering from chronic knee discomfort. This suggests that the supplement could be a helpful option for managing knee pain in older adults.
References
- Toguchi A, Noguchi N, Kanno T, Yamada A. Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2023;15. 10.3390/nu15132995
- Tennent DJ, Hylden CM, Kocher BK, Aden JK, Johnson AE. A randomized controlled trial evaluating methylsulfonylmethane versus placebo to prevent knee pain in military initial entry trainees. US Army Med Dep J. 2017.
- Nieman DC, Shanely RA, Luo B, Dew D, Meaney MP, et al. A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial. Nutr J. 2013;12:154. 10.1186/1475-2891-12-154
- Debbi EM, Agar G, Fichman G, Ziv YB, Kardosh R, et al. Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study. BMC Complement Altern Med. 2011;11:50. 10.1186/1472-6882-11-50
- Kim LS, Axelrod LJ, Howard P, Buratovich N, Waters RF. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage. 2006;14:286.
